2 official rulings from Bandai, last ruled Mar 28, 2024. Straight answers to how this card actually resolves.

Does this card's "if there are 3 or more Digimon in play" refer to 3 or more total Digimon in play by both me and my opponent?
Yes, that's correct.
Ruled Mar 28, 2024
Can I activate just the "delete 1 Digimon without [X Antibody] in its traits" effect when there are 3 or more Digimon in play?
No, you can't. When there are 3 or more Digimon in play, you must delete all Digimon without [X Antibody] in their traits.
Ruled Mar 28, 2024
Got a line that uses X Program? Map it in the builder and share it with a link.
Questions and answers are Bandai's official rulings, collected and translated by the DigimonCardGame Wiki community and reused here under CC BY-SA. Card names and card text are © their respective publishers; Combalo is not affiliated with Bandai.